I would say one of my favorite moments is when Sanctuary turns inot a sky city. Plus, Handsome Jack is a great villain.

It was a fun game for multiplayer (which are so few and far between for PS). All you
had to do was play 2 mechromancers and you could destroy everything.

Oh man, multiplayer Borderlands 2 is amazing. I played several hours with a friend of mine and we just went straight through to the end of the story. Then we just did quests for fun.