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Different active ingredients, similar effect. I've heard bad things about trips on either of these substances. Sort of like, just because you can, doesn't mean you should.
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i did a whole bunch of benadryl once, if you ever decide you really want to know what delirium is like, you should give it a try. i was incoherent for a good eight hours, hallucinating like crazy. it puts you in that place right between dreaming and waking, so you'll start seeing things while you're still awake and then pass out into really epic and elaborate dreamworlds. it's not exactly fun, but it's pretty interesting and intense.
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I think if you could imagine tripping on DMT with the stupidity of being really drunk you would get pretty close to what Benadryl is like.
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I prefer Tramadol tid. It's prescribed for pain in the US, but is also prescribed in Europe as an anti-depressent. It tends to clear my head and increase mood. Works great to take 50-100mg an hour or two before getting up in the morning, especially if you had several drinks the night before. Also later in the day when brain fog kicks in. All meds affect people differently, but tramadol has no side effects for me. Safe, cheap, reliable and (I don't really care if it is or isn't) legal.
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my favorite hangover cure is pot. safe, cheap, reliable and illegal.
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