It's hard to tell when thinking only of bands that started in or after 2000. I'll try a few, only including ones I'm nearly 100% confident will still be talked about by large groups of people. And this has nothing to do with personal preference, except that I'm only looking through my personal collection/stuff I've heard to compile the list as I obviously can't include stuff I'm not familiar with.
The Mars Volta
ISIS
Mastodon
Animal Collective
The Shins
TV on the Radio
Arcade Fire (unfortunately)
Prefuse 73
A Perfect Circle
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