Originally Posted by Conan

It won't work very well unless your guitar is very out-of-tune, and even then most auto-tune VSTs don't like fuzz or distortion when they are affecting a track. Although I guess you could manually adjust the pitch, which most plug-in versions allow you to do - it's just really hard to get that signature sound, I prefer to put it in the key I want and flip a few panels and it does it for me... not that I ever seriously use it.