The guitar solo in Hysteria by Muse.
One of the most awesome riffs in the history of riffdom, topped with an incredible, nay, amazing song - and then that guitar solo.
Matt may be a great singer, and a great pianist, and a great riffer - but he should leave solos to those who can play them, IMHO.
/grabs coat and runs from legions of angry Muse fans who actually rather like the solo...