We build some pretty huge particle generators to look for particles that we, as humans, are not able to "experience" as such other than in a theoretical sense. But I think I get what you mean roughly - good science is provable and possibly there are parts of the ultimate truth that are just not testable in any such way and so we won't know for sure.
None of us can actually know if a tree would make a sound in the forest if it fell and nothing was there to witness it. Although we roughly agree that it should do, maybe the ultimate truth is that it doesn't. We won't ever know because as soon as something is there to record or observe the phenomena, you've already failed the experiment.
I'll argue again, though, that although parts of the truth may be unprovable, some parts are provable and as long as scientific breakthroughs let us do stuff in new ways, that itself proves that we are piecing together more of the truth .. even if at some point we find out there that we can't get any further.
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