Now, for my favorite handgun caliber: the
10mm Auto. For the stopping power vs. round size, it's hard to beat. This thing is not only a man / beast killer, but it's accurate to further distances than most other large calibers.
For the gun, there is just no beating the Rock Island Armory / ArmsCor Pro Match Ultra HC 1911. Not only is it a 1911, so you know it's reliable as f
uck, but it sports a double stack magazine, so you get the high [
16+1] capacity that you want want as well. It has a
6" barrel, front and rear cocking serrations an MSRP of around
$1,300 USD.
You'll want to pair that with some good ammunition, like the
155-grain Underwood XTP jacketed hollow point, which can achieve muzzle velocities of up to
774 ft-lbs. With
17 rounds at your disposal, that gives you
13,158 ft-lbs of stopping power.
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Now, if it was up to me, I would have ended with the 10mm Auto, but no list is complete without what is possibly the most ubiquitous handgun caliber out there, the 9mm. The longtime favorite of military and law enforcement alike, you can find them at as many places as the .22 LR, the world's post popular round.
For the gun, FN makes it's third appearance on this list, with the FN 509 Tactical. It sports an impressive 17+1 capacity, but an extended magazine ups that to 24+1. It has a 4.5" threaded barrel and a MSRP of around $1,050 USD.

And you've gotta have good ammo, like the 64-grain MagSafe +P Max, with a muzzle energy of up to 540 ft-lbs. Pair that with the insane 25-round capacity, and you've got 13,500 ft-lbs of stopping power in your hands.

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If you would like to see any other reviews of handguns or ammo, let me know!