I'm no doper, but I once knew that practice as I was a child of the 60's.
Here's what I think:
Pot: Not sure, some people get tachycardia from it. I gotta wonder about bronchial & lung damage due to the high temp when smoked.
Acid: gets old over time, risk of psychotic episodes. Haldol will turn it off , usually.
Mescaline: sparkly shimmering cities. There was a time I wanted to try peyote...
Meth: downright dangerous
Painkillers, Opiates: Addictive & potentially permanent brain damaging.
Cocaine: immediately orgasmic, leads to severe crashes, not worth it.
Nicotine: a self destructive way to induce relaxation when inhaled via tobacco . Killed my parents, one was emphysema (hideous), other was congestive heart failure. Kissing a smoker is like licking an ashtray. No matter how it is used, it eats your heart (literally). It was an absolute bitch to give it up, but give it up I did.
Alcohol: addictive & problematic for many, it probably has to do with genetics.
All of the later stuff came after I recognized the full dangers of chemical entertainment, so I don't know! Try meditation or exercise, self medicating is dangerous & destructive.