I know you didn't mean mental illness per se but I do have a friend with schizophrenia. It tends to be episodic in that she will go off her meds, drink, do too many drugs, lose it completely, go to hospital, get her life back together, cruise along for a bit, go off her meds...
The episodes used to almost be pleasurable for her with fairies and harmless fantasy but her last episode was brutal. She was extremely paranoid and was locked up for fighting with strangers she thought had said something to her. By the time she was hospitalised she was skin and bone and just a wreck emotionally. Really sad to see her get that bad.
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