Hardware? Access Virus, or pretty much any Access synth. I have the Indigo 2 and it's a beast.
Software-wise, there are tons. Rob Papen's Albino 3 is pretty gnarly. Sports 4 oscillators, 4 independent LFOs, 2 filters (with cream and scream as well) and 4 modes of saturation, all your standard effects, modulation matrix, and an arpeggio. The presets aren't anything to brag about, but you can make some sinful sounds on it relatively easy if you know basic synthesis concepts.
Price-wise, you're better off with the software synth and a midi keyboard.
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